ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.

By Thorsten Maretzky, K. Reiss, A. Ludwig, Julian Buchholz, Felix Scholz, E. Proksch, B. de Strooper, D. Hartmann, P. Saftig. Proceedings of the National Academy of Sciences of the United States of America, 2005

675 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/6a200d08776254e65355b4e34b8ec355d7c84af2

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In Molecular Biology

1. T. Valenta
2. G. Hausmann
3. Konrad Basler
4. D. Edwards
5. V. Plaks
6. Mahmut Yilmaz
7. K. Kessenbrock
8. M. Handsley

In Oncology

1. Zena Werb
2. V. Plaks
3. D. Edwards
4. K. Kessenbrock
5. M. Handsley
6. Gerhard Christofori
7. W. Nelson
8. C. Pennington

Citations in the corpus

• The ADAM metalloproteinases (2008, background): “But in addition to Notch/ Delta, ADAM-10 has many other biologically relevant targets, including ephrin-A5 and E-cadherin ( (Janes et al., 2005; Maretzky et al., 2005a) ; Table 1 ).”
• Matrix Metalloproteinases: Regulators of the Tumor Microenvironment (2010, background): “Interestingly, ADAM-10 mediates the shedding of E-cadherin, which results in β-catenin 56 Cell 141, April 2, 2010 ©2010 Elsevier Inc. translocation to the nucleus, driving cell proliferation (Maretzky et al., 2005).”
• EMT, the cytoskeleton, and cancer cell invasion (2009, background): “On the post-translational level, the transport of newly synthesized E-cadherin to the cell membrane can be inhibited via O-glycolysation [51] or mature, membranebound E-cadherin can be degraded by proteolytic cleavage or endocytosed from the plasma membrane [52–55].”
• Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. (2006, positive): “Cadherins are targets of ADAM (a disintegrin and metalloprotease domain) 10 (Maretzky et al. 2005; Reiss et al. 2005) that cleaves the cadherin extracellular domain close to the transmembrane domain (Fig.”
• The many faces and functions of β‐catenin (2012, positive): “In the nucleus b -catenin activates transcription of Wnt/ b -catenin-target genes such as c-myc and cyclinD1 (Maretzky et al , 2005; Reiss et al , 2005).”