A critique of functional localisers

By Karl J. Friston, Pia Rotshtein, Joy J. Geng, Philipp Sterzer, Richard N. Henson. NeuroImage, 2006

428 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Geometry and Topology

View Paper: https://www.semanticscholar.org/paper/698c6deaa4cf1a576a8775d24ca7c0bf7f6e3b5d

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Citations in the corpus

Behavioral / Systems / Cognitive Striatal Prediction Error Modulates Cortical Coupling (2010, positive): “To accommodate intersubject variability in the exact location of FFA and PPA, we identified these regions for each subject separately, using an embedded orthogonal localizer contrast (i.e., the main effect of faces versus houses and vice versa) (Friston et al., 2006).”
Meta-analysis of functional magnetic resonance imaging studies of inhibition and attention in attention-deficit/hyperactivity disorder: exploring task-specific, stimulant medication, and age effects. (2013, methodology): “However, the analysis included region-of-interest FMRI analyses,(38) which provide a constrained characterization of functional anatomy.(39) Also, likely due to limited methods and study availability at the time, meta-analyses were performed across group maps, rather than on coordinates of differenc”
Building a Science of Individual Differences from fMRI. (2016, background): “However, they quickly become inefficient if one wants to map many different processes in a study [43].”
Disease state prediction from resting state functional connectivity (2009, methodology): “Time courses were extracted from every voxel in an ROI and reduced to the first eigenvariate from singular value decomposition (38).”
Effects of motivation on reward and attentional networks: an fMRI study (2012, background): “The use of orthogonal localizing contrasts protects against biased sampling (Friston et al. 2006).”
Posture influences motor imagery: An fMRI study (2006, methodology): “Therefore, we could use this prior information to constrain our search space (Friston et al., 2006).”
Imaging the deep cerebellar nuclei: A probabilistic atlas and normalization procedure (2011, neutral): “The method combines the spatial specificity of ROI analyses and the information richness of map-wise approaches (for a debate between these two approaches see: Friston et al., 2006; Saxe et al., 2006).”
Effects of transcranial direct current stimulation (tDCS) on human regional cerebral blood flow (2011, background): “SPM's first eigenvariate is its estimated weighted mean of the VOI, in this case the time course of rCBF (Friston et al., 2006).”
Neuroimaging of child abuse: a critical review (2012, background): “Examining previously defined ROIs restricts the search toward a priori hypothesized regions thus providing a biased and inappropriately constrained characterization of anatomy (Friston et al., 2006).”
A whole brain fMRI atlas generated via spatially constrained spectral clustering (2011, methodology): “ROI summary time courses were derived either by averaging (a–c) or using the first eigenvariate of a principle components analysis (PCA) (d–f).”
Visual field maps in human cortex. (2007, neutral): “There is an interesting debate about the value of ROI measurements and the optimal implementation of localizer scans (Friston et al., 2006; Saxe et al., 2006).”
Circular analysis in systems neuroscience – the dangers of double dipping (2009, neutral): “For example, consider the selection contrast A+B (cselection = [1 1]) and the test contrast A-B (ctest = [1 -1]).”
Temporo-parietal Junction Activity in Theory-of-Mind Tasks: Falseness, Beliefs, or Attention (2009, background): “Future research needs to look into this methodological issue, which is one of those research scenarios in which a separate localizer experiment provides the appropriate design (Friston, Rotshtein, Geng, Sterzer, & Henson, 2006 ) to break the unwanted context effect.”
The Decoding Toolbox (TDT): a versatile software package for multivariate analyses of functional imaging data (2015, background): “…ROIs, but require no prior selection of brain regions and are in that respect unbiased to prior assumptions about where to expect an effect (Friston et al., 2006); however, they suffer from the multiple comparisons problem, the necessity to specify the searchlight size as an additional…”