Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer.

By P. Salama, M. Phillips, F. Grieu, M. Morris, N. Zeps, D. Joseph, C. Platell, B. Iacopetta. Journal of Clinical Oncology, 2009

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gp100 Peptide Vaccine and Interleukin-2 in Patients with Advanced Melanoma (2011, neutral): “Renal or genitourinary 14 (15) 16 (19) 0.”
Regulatory T Cells and Human Disease. (2020, background): “In colorectal cancer (CRC), however, there are several reports that increased FOXP3 expression in tumor tissue is associated with a better prognosis, while other reports show its association with poor prognosis (152, 153).”
PD-1-expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-associated head and neck cancer. (2013, background): “also those with an unexpected clinical benefit of Treg infiltration (17, 39, 40).”
Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours (2013, background): “Furthermore, CRCs from a large cohort (n = 1197) and external validation (n = 209) confirmed the prognostic value associated with CD3+, CD8+ and CD45RO+ (PTPRC) T cell infiltration in CRCs [43].”
Immune infiltration in human tumors: a prognostic factor that should not be ignored (2010, background): “In a recent publication, Salama et al. (2009) reported an analysis of T-cell infiltrates in 967 colorectal tumors including 593 with stage II and 374 with stage III.”
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. (2011, neutral): “, 2005) and FOXP3 (Frey et al., 2009; Salama et al., 2009).”