Hydrogen Sulfide Mediates Cardioprotection Through Nrf2 Signaling

By J. Calvert, S. Jha, S. Gundewar, J. Elrod, A. Ramachandran, C. Pattillo, C. Kevil, D. Lefer. Circulation Research, 2009

697 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders (2010, neutral): “H 2 S appears to increase GSH levels by activating g -glutamyl- cysteine synthetase (114).”
H2S ameliorates oxidative and proteolytic stresses and protects the heart against adverse remodeling in chronic heart failure. (2010, result): “These findings extended concrete support to other findings that H2S is a cardioprotective gas (3, 4, 8).”
Protective Actions of H2S in Acute Myocardial Infarction and Heart Failure (2017, positive): “tioning, in which it has been reported that H2S can upregulate the CO/HO-1 signaling in an Nrf2-dependent manner (22).”
Hydrogen sulfide and cell signaling. (2011, background): “NaHS also induces the nuclear localization of the transcription factor Nrf-2 (NF-E2-related factor 2) in rat hearts during experimental myocardial ischemia (94).”
Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. (2012, methodology): “applied Na2S (100 g/kg iv) to mice 24 h before myocardial ischemia (91).”