Hydrogen sulfide and cell signaling.
By Ling-Xia Li, P. Rose, P. Moore. Annual Review of Pharmacology and Toxicology, 2011
1,230 citations recorded by the source corpus.
Hydrogen sulfide (H₂S) is a gaseous mediator synthesized from cysteine by cystathionine γ lyase (CSE) and other naturally occurring enzymes. Pharmacological experiments using H₂S donors and genetic experiments using CSE knockout mice suggest important roles for this vasodilator gas in the regulation of blood vessel caliber, cardiac response to ischemia/reperfusion injury, and inflammation. That H₂S inhibits cytochrome c oxidase and reduces cell energy production has been known for many decades, but more recently, a number of additional pharmacological targets for this gas have been identified. H₂S activates K(ATP) and transient receptor potential (TRP) channels but usually inhibits big conductance Ca²(+)-sensitive K(+) (BK(Ca)) channels, T-type calcium channels, and M-type calcium channels. H₂S may inhibit or activate NF-κB nuclear translocation while affecting the activity of numerous kinases including p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase (ERK), and Akt. These disparate effects may be secondary to the well-known reducing activity of H₂S and/or its ability to promote sulfhydration of protein cysteine moieties within the cell.
Subfields: Biochemistry, Physiology
View Paper: https://www.semanticscholar.org/paper/6516f59b5db9f0e28ce125fc9990fd0728747214
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Citations in the corpus
- Hydrogen sulfide-linked sulfhydration of NF-κB mediates its anti-apoptotic actions (2012, background): “In WT mice, we detect a large number of red bands, representing proteins with SH as well as SSH substituents, with a 50% reduction after DTT treatment.”
- Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer (2013, neutral): “Arterioscler Thromb Vasc Biol 30(10):1998–2004.”
- Hydrogen sulfide is involved in the chilling stress response in Vitis vinifera L. (2013, background): “10) [34], and CBS and CSE consistently demonstrated to produce H2S in mammalian tissues [1,35].”
- Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation (2012, background): “These responses likely involve parallel pathways of H2S-induced vasorelaxation, such as KATP channels (24, 25) and other types of potassium channels and the ion exchangers (17).”