Mechanisms of antibiotic resistance in enterococci

By William R. Miller, J. Munita, C. Arias. Expert Review of Anti-Infective Therapy, 2014

685 citations recorded by the source corpus.

Multidrug-resistant (MDR) enterococci are important nosocomial pathogens and a growing clinical challenge. These organisms have developed resistance to virtually all antimicrobials currently used in clinical practice using a diverse number of genetic strategies. Due to this ability to recruit antibiotic resistance determinants, MDR enterococci display a wide repertoire of antibiotic resistance mechanisms including modification of drug targets, inactivation of therapeutic agents, overexpression of efflux pumps and a sophisticated cell envelope adaptive response that promotes survival in the human host and the nosocomial environment. MDR enterococci are well adapted to survive in the gastrointestinal tract and can become the dominant flora under antibiotic pressure, predisposing the severely ill and immunocompromised patient to invasive infections. A thorough understanding of the mechanisms underlying antibiotic resistance in enterococci is the first step for devising strategies to control the spread of these organisms and potentially establish novel therapeutic approaches.

Subfields: Infectious Diseases, Molecular Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/69059fc2d9b9fd61b5b05a81112db27175769d2a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. J. Munita
2. C. Arias

In Molecular Medicine

1. E. Peterson
2. P. Kaur
3. J. Munita
4. W. Reygaert
5. C. Arias

In Pharmacology

1. E. Peterson
2. P. Kaur
3. J. Munita
4. W. Reygaert
5. C. Arias

Citations in the corpus

• Antibiotic Resistance Mechanisms in Bacteria: Relationships Between Resistance Determinants of Antibiotic Producers, Environmental Bacteria, and Clinical Pathogens (2018, background): “Another example of target modification is vancomycin resistance, which results from acquisition of the van gene cluster and is commonly a problem in enterococci (Miller et al., 2014).”
• Mechanisms of Antibiotic Resistance (2016, background): “…of D -Ala for D -Ser does not remove any of the fi ve hydrogen bonds between vancomycin and its target, the presence of the hydroxyl group of serine affects the interaction of the antibiotic with the precursors, reducing its af fi nity, albeit less markedly than with the D -Lac replacement (74).”
• An overview of the antimicrobial resistance mechanisms of bacteria (2018, background): “These strains are designated as VISA strains [30,32].”