A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9

By M. Donoghue, F. Hsieh, E. Baronas, Kevin Godbout, Michael L. Gosselin, N. Stagliano, M. Donovan, Betty Woolf, K. Robison, R. Jeyaseelan and 2 more. Circulation Research, 2000

2,919 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/68d83a261254685e92c4d6959cb2b71ac40610a1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. M. Grant
2. J. Zhong
3. Vaibhav B. Patel
4. G. Oudit

In Genetics

1. M. F. Holick

In Molecular Biology

1. M. Grant
2. J. Zhong
3. P. McCray
4. Josef M. Penninger
5. T. Wada
6. Vaibhav B. Patel
7. G. Oudit
8. P. Masters

Citations in the corpus

• Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System (2020, background): “Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor.”
• Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus (2003, background): “Here we identify a metallopeptidase, angiotensin-converting enzyme 2 (ACE2”
• Angiotensin-converting enzyme 2 is an essential regulator of heart function (2002, background): “Recently, a homologue of ACE, termed ACE2, has been identified; it is predominantly expressed in the vascular endothelial cells of the kidney and hear”
• Role of the ACE2/Angiotensin 1–7 axis of the Renin-Angiotensin System in Heart Failure (2016, methodology): “teinase catalytic domains of ACE2 and ACE are 42% identical according to the findings of Donoghue et al.(32) In spite of such”
• The pivotal link between ACE2 deficiency and SARS-CoV-2 infection (2020, positive): “[2,3] The ACE2 receptor, discovered by two independent groups in year 2000, [4,5] is a trans-membrane type I glycoprotein (mono-carboxypeptidase) composed by 805 amino acids which uses a single extracellular catalytic domain to remove one single amino acid from the octapeptide angiotensin II to gene”
• ACE2 Receptor Expression and Severe Acute Respiratory Syndrome Coronavirus Infection Depend on Differentiation of Human Airway Epithelia (2005, background): “sue, and epithelia of the small intestine and testes (6, 10, 11).”
• In silico SARS-CoV-2 vaccine development for Omicron strain using reverse vaccinology (2022, methodology): “In the final step we performed molecular docking of the vaccine candidate with human ACE2 (Donoghue et al. 2000).”