Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach

By C. Manichanh, L. Rigottier-Gois, E. Bonnaud, K. Gloux, É. Pelletier, L. Frangeul, R. Nalin, C. Jarrin, P. Chardon, P. Marteau and 2 more. Gut, 2005

2,282 citations recorded by the source corpus.

Subfields: Genetics, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/68afe48d1d0734e59e6dad03693ca4b7110eb29d

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Citations in the corpus

Metagenomic biomarker discovery and explanation (2011, background): “For example, single pathogenic organisms can signal disease if present in a community [21,22], and increases and decreases in community complexity have been observed in bacterial vaginosis [23] and Crohn’s disease [8].”
Analysis of the Lung Microbiome in the “Healthy” Smoker and in COPD (2011, background): “Thus, in the lungs, as with other sites on the mucosa, a diverse microbiota may be important for health, including colonization resistance, epithelial integrity, and immunoregulation [33,34].”
Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation (2013, background): “Interestingly, reduced microbial diversity was associated with diseases such as Crohn’s disease [Manichanh et al. 2006] and eczema in early life [Forno et al. 2008].”
Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum (2007, background): “The relative decreases in a subset of Clostridiales we detected in ICD mirrors recent studies of feces and colonic mucosa from patients with CD, and suggests that this alteration may be a feature of CD in general rather than a specific phenotype (Gophna et al., 2006; Manichanh et al., 2006; Martinez”
The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age (2009, background): “This has markedly increased the information available concerning the complexity of the human bowel microbiota, from which over 1250 Operational Taxonomic Units have been identified corresponding to several dominant phyla [4,5].”
The gut microbiota and host health: a new clinical frontier (2015, background): “65 Changes in the two dominant phyla, Firmicutes and Bacteroidetes, are coupled with an increase in abundance of members of the Proteobacteria phylum, which have been increasingly found to have a key role in IBD.”
Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent (2013, background): “Intestinal disorders, such as inflammatory bowel diseases [22-25], irritable bowel syndrome [26], colorectal cancer [27,28] and obesity [29] have all been reported to be associated with a diminished prevalence and abundance of F.”