Latent TGF-β structure and activation
By Minlong Shi, Jianghai Zhu, Rui Wang, Xing Chen, L. Mi, Thomas Walz, T. Springer. Nature, 2011
956 citations recorded by the source corpus.
Subfields: Immunology and Allergy, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/68a8cf39b053512550f7f5094b07c092e1e19615
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In Immunology and Allergy
In Molecular Biology
Citations in the corpus
- Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “Recent analysis of the causes of resistance to anti-VEGF therapy points to an important role of tumor-infiltrating leukocytes in providing other angiogenic signals (Casanovas, 2011; Shojaei and Ferrara, 2008).”
- TGF-β1 Signaling and Tissue Fibrosis. (2018, background): “Similar requirements were shown for avb6-mediated TGF-b activation by epithelial cells (Giacomini et al. 2012), although the role, if any, of mechanical force in TGF-b activation by avb8 is less clear (Mu et al. 2002). avb6-mediated TGF-b1 activation was also shown to require covalent disulfide link”
- Transforming Grown Factor-β Signaling in Immunity and Cancer (2019, neutral): “The crystal structure of this complex revealed that LAP encircles the active TGF-β portion and hinders the relevant contact sites of the cytokine with their cognate heterotetrameric receptors (Shi et al., 2011).”
- Selective αv integrin depletion identifies a core, targetable molecular pathway that regulates fibrosis across solid organs (2013, positive): “The recently solved crystal structure of the small latent complex of TGF-β demonstrates that mechanical force generated by the contractile actomyosin cytoskeleton and transmitted by integrins is a common mechanism for activating latent TGF-β 12 .”
- TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019 (2019, background): “The LTC is then released and deposited in the surrounding ECM through binding to latent TGF-β binding protein (LTBP), forming the large latent complex (LLC) [22].”
- TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis (2019, background): “The amino-terminal part is also termed the latency associated peptide (LAP) and is noncovalently attached to the mature TGF-β [9,10].”
- Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer—How We Can Rise to the Challenge (2019, background): “Several challenges remain ahead of TGF-β-based TNBC therapy, including selectivity/specificity issues of TGF-βR inhibitors and the accessibility of the TGF-β to mAbs [58].”
- TGF-β Activation and Function in Immunity (2013, background): “proteolytic cleavage sites and suggested how proteases could lead to release of free active TGF-β from the LAP latency lasso (4).”