Tissue oxygen tension and brain sensitivity to hypoxia.

By M. Erecínska, I. Silver. Respiration Physiology, 2001

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Oxygen in stem cell biology: a critical component of the stem cell niche. (2010, background): “Oxygen measurements of tissues known to harbor stem cells revealed even lower oxygen tensions, and raised the question of whether such an environment was necessary for the niche to maintain stem cells (Braun et al., 2001; Cipolleschi et al., 1993; Erecinska and Silver, 2001).”
Hypoxia and adipose tissue function and dysfunction in obesity. (2013, background): “It should also be noted, as discussed earlier, that physiologically several other tissues, including the retina, parts of the brain, and tumors have a similar, or lower, O2 tension (13, 41, 227).”
Clinical review: Hemorrhagic shock (2004, background): “Conversely, brain cells sustain permanent damage after only a few minutes of hypoxia [ 25 ].”
Energy limitation as a selective pressure on the evolution of sensory systems (2008, background): “The need for a constant supply of oxygen to the brain to maintain function is emphasized by the consequences of an interruption to the blood supply to the mammalian brain: a decrease in blood flow below critical levels can cause a 90% drop in ATP within 5min (Erecinska and Silver, 2001).”