Targeting metastasis-initiating cells through the fatty acid receptor CD36
By Gloria Pascual, A. Avgustinova, S. Mejetta, Mercè Martín, A. Castellanos, C. Attolini, A. Berenguer, N. Prats, A. Toll, J. Hueto and 3 more. Nature, 2016
1,280 citations recorded by the source corpus.
Subfields: Cancer Research, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/683f67199926f36aee244de7c4e328814cb6edbb
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In Cancer Research
- Thomas Brabletz
- B. Faubert
- Harald Schuhwerk
- Simone Brabletz
- Marc P. Stemmler
- Ashley Solmonson
- Ralph J. Deberardinis
- J. Rathmell
Citations in the corpus
- Chemotherapy Resistant Human Acute Myeloid Leukemia Cells are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism (2017, background): “Thus, as shown in carcinoma metastasis (51), cachexia (52), or CML (49), upregulation of CD36 might drive intracellular FA metabolism, increases FAO, maintains OXPHOS state and activity of RLCs by fueling long-chain FA uptake from the extracellular bona marrow matrix and medullar adipocytes, and pro”
- Dynamic EMT: a multi‐tool for tumor progression (2021, positive): “The presence of CD36 promotes EMT in HCC and is crucial for metastatic colonization of oral cancer (Nath et al , 2015; Pascual et al , 2017; Bergers & Fendt, 2021).”
- Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications (2017, background): “Indeed, it has been recently shown that cancer cells that express high levels of the fatty acid receptor CD36 and lipid metabolism genes, are unique in their ability to initiate metastasis in the presence of an excess of dietary fat (Pascual et al., 2017).”
- Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy. (2020, background): “Interestingly, very low carb or ketogenic diets have boosted some anti-cancer immunotherapies (Soldati et al., 2018) whereas high-fat diets may exacerbate malignancies (Pascual et al., 2017).”
- Metabolic reprogramming and cancer progression (2020, background): “CD36 expression is both necessary and sufficient for these cells to give rise to lymph node metastases at high efficiency (97).”