Matrix metalloproteinases in tumor invasion and metastasis.

By I. Stamenkovic. Seminars in Cancer Biology, 2000

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TGF-β signaling in tumor suppression and cancer progression (2001, background): “12 ), which are frequently expressed by malignant cells, especially at sites of tumor cell invasio”
Extracellular matrix remodelling: the role of matrix metalloproteinases (2003, background): “However, numerous cytokines and growth factors as well as physical cellular interactions provide stimuli that can rapidly induce MMP expression (reviewed in [10] and references therein).”
Matrix metalloproteinases and tumor metastasis (2006, background): “These observations appear to clearly implicate MMPs of both tumor and stromal origin in the induction of metastasis [8, 14, 23, 24, 56, 62, 116, 117].”
Interstitial flow and its effects in soft tissues. (2007, background): “The clinical relevance of such treatments is still unclear, however, as disruption of the tumor ECM not only allows easier interstitial transport of potential therapeutics, but it also lowers the barriers to tumor cell metastasis (123, 124).”
Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. (2002, methodology): “Figure 2 shows that MCP-1 is cleaved at Ala4-Ile5, designated MCP-1(5-76); by MMP-1; to a lesser extent (20% of total by densitometric analysis) by MMP-3; and to a very minor extent (5% of total) by MMP-8.”