Axon retraction and degeneration in development and disease.

By Liqun Luo, D. O'Leary. Annual Review of Neuroscience, 2005

854 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/67d4d74fad0140395fd8f280274394ac0ee46535

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In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

The neuroscience of human intelligence differences (2010, positive): “…brains, greater grey matter volumes and thicker cortices usually are associated with more neurons, it is unclear how and why this should lead to better intellectual performance, especially as brain development — and presumably intelligence development — involves substantial neuronal pruning 68 .”
Functional Brain Networks Develop from a “Local to Distributed” Organization (2009, background): “Pruning is also largely activity dependent, and is considered critical in the differentiation of distinct functional areas [56,66,67].”
N-APP binds DR6 to cause axon pruning and neuron death via distinct caspases (2009, background): “4g), (2) its ectodomain can be shed in a regulated fashion(19,20), and (3) it is tied to degeneration through its links to Alzheimer’s disease.”
Role of Mechanical Factors in the Morphology of the Primate Cerebral Cortex (2006, background): “Another key regressive event in development is the elimination of exuberant axons [59], which likely contributes to establishment and modification of convolutions as well.”
Immune modulation of learning, memory, neural plasticity and neurogenesis. (2011, neutral): “ciently functioning neural circuits (Luo and O’Leary, 2005).”
Programmed Cell Death in Animal Development and Disease (2011, neutral): “excessive or inaccurate projections without resulting in the death of the cell (Luo and O’Leary, 2005).”
Age Differences in Hippocampal Subfield Volumes from Childhood to Late Adulthood (2015, background): “In younger age, the combination of selective neuronal pruning (see Luo and O’Leary, 2005; Holtmaat and Sboboda, 2009 for reviews) and neuropil changes, with possible local contribution of neurogenesis (Gould, 2007) may affect subfield volumes.”
Classification of cell death (2005, neutral): “Additional less-characterized forms of cellular catabolism take place in the nervous system, such as Wallerian degeneration, in which part of a neuron or axon degenerates without affecting the main cell body.(69,70) This term does not describe a type of cell death sensu stricto, because neurons affe”
The biophysics of neuronal growth (2010, background): “However, the final branching pattern of neurons is not only established by branch addition and maintenance but also by branch retraction and elimination [19].”
Temporal dynamics and genetic control of transcription in the human prefrontal cortex (2011, background): “This coordinated reversal of expression trajectories among axonal genes while many synaptic genes continue to increase in infancy is probably a genomic view of the process of pruning exuberant axons while synapse development and maturation at appropriate target sites advanc”