Neuronal activity-dependent control of postnatal neurogenesis and gliogenesis
By R. Káradóttir, C. Kuo. 2018
35 citations recorded by the source corpus.
Addition of new neurons and oligodendroglia in the postnatal/adult mammalian brain present distinct forms of grey and white matter plasticity. Substantial effort has been devoted to understanding the cellular and molecular mechanisms controlling postnatal neurogenesis and gliogenesis, revealing important parallels to principles governing the embryonic stages. While during CNS development, scripted temporal and spatial patterns of neural and glial progenitor proliferation/differentiation are necessary to create the nervous system architecture, it remains unclear what may be the driving forces that maintain and sustain postnatal neural stem cell (NSC) and oligodendrocyte precursor cell (OPC) production of new neurons and glia. In recent years, neuronal activity has been identified as an important modulator of these processes. Utilizing the distinct properties of neurotransmitter ionotropic and metabotropic channels to signal downstream cellular events, NSCs and OPCs share common features in their readout of neuronal activity patterns. Here we review the current evidence for neuronal activity-dependent control of NSC/OPC proliferation and differentiation in the postnatal brain, highlight some potential mechanisms used by the two progenitor populations, and discuss future studies that might advance these research areas further.
Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience
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Citations in the corpus
- Continual Learning via Neural Pruning (2019, methodology): “ing a new task, the connections of these pruned neurons are reinitialized in amanner reminiscent of the lifecycle of biological neurons [6].”