Class II histone deacetylases: versatile regulators.

By E. Verdin, F. Dequiedt, H. Kasler. Trends in Genetics, 2003

674 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/65e38ae32e8ca195c28eca50baea22da9556874c

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In Cellular and Molecular Neuroscience

E. Verdin

In Molecular Biology

Citations in the corpus

Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. (2004, background): “Recently, these subfamilies have also been called 2a and 2b, respectively.(48)”
Sirtuins: Sir2-related NAD-dependent protein deacetylases (2004, background): “Class I and class II HDACs, which share significant similarity to each other in their catalytic cores, are homologs of the yeast deacetylases Rpd3p and Hda1p, respectively (reviewed in [2,3]).”
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. (2004, background): “In contrast, the (1)Department of Molecular Biology class II HDACs (HDAC 4, 5, 7, and 9) display cell type2 Department of Pathology restricted patterns of expression and contain an N-ter3 Department of Internal Medicine minal extension that links them to specific transcription University of Texas So”
HDAC family: What are the cancer relevant targets? (2009, background): “Hdac7 is specifically expressed in the vascular endothelium during early embryogenesis, where it maintains vascular integrity by repressing the expression of matrix metalloproteinase 10 by associating with myocyte enhancer factor-2 (MEF2) [32].”
Histone acetyltransferase complexes: one size doesn't fit all (2007, background): “Accordingly, because HATs are recruited to chromatin through methylated histones, which results in transcriptional activation, it is possible that sumoylation not only inhibits HAT recruitment, but it might also facilitate the recruitment of other negatively acting complexes, such as HDACs, which ar”
Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. (2007, background): “The class II HDACs (HDAC4, HDAC5, HDAC7, and HDAC9) are homologous to the yeast protein HDA1 and are enriched in muscle and neural tissues (Grozinger et al. 1999; Verdin et al. 2003).”
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men (2008, background): “HDACs can also be grouped according to phylogenetic analysis and sequence homolog”