Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

By M. Ono, H. Yaguchi, Naganari Ohkura, I. Kitabayashi, Yuko Nagamura, T. Nomura, Y. Miyachi, T. Tsukada, Shimon Sakaguchi. Nature, 2007

718 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/6516b4ce7b2e812b8ca30009bca9d1d40e74d660

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In Immunology

Citations in the corpus

Regulatory T cells and immune tolerance. (2008, background): “It is expressed in conventional T cells and to a slightly lesser degree in natural Tregs (Ono et al., 2007).”
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells (2007, background): “T reg cells show some 'anergic' activity and produce no interleukin 2 (IL-2), presumably because of the transcriptional repression effects of Foxp3, a putative lineage-specific transcription facto”
Regulatory T Cells and Human Disease. (2020, background): “It may also be an activator to enhance the expression of Treg-DR-dependent genes by binding to their promoters (together with other transcription factors such as Runx1/CBFβ and Eos) upon Treg activation (49).”
Peripheral CD4 T cell differentiation regulated by networks of cytokines and transcription factors (2010, background): “In addition, this complex both positively regulates Treg-specific gene expression (99–102) and negatively regulates genes not expressed in Tregs, such as IL-2 (103).”
Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “Among sequence-specific transcription factors serving as Foxp3-interaction partners, NFAT and Runx1 were proposed to be indispensable for establishing Treg cell transcriptional and functional programs (159, 160).”
The emerging roles of forkhead box (Fox) proteins in cancer (2007, background): “Recent research suggests that the transcriptional target specificity and activity of FOXP3 is also regulated through complex formatio”
Development and maintenance of regulatory T cells. (2013, background): “Notably, however, both Foxp3 expression and Treg-cell-type DNA hypomethylation are involved in controlling the expression of some Treg-cell-function-associated molecules, such as Il2ra,Ctla4, and Foxp3 itself, especially upon TCR stimulation (Hill et al., 2007; Hori et al., 2003; Ono et al., 2007).”
T-bet controls regulatory T cell homeostasis and function during type-1 inflammation (2009, background): “In addition, Foxp3 can directly repress Ifng expression, and chromatin-immunoprecipitation studies have detected Foxp3 bound to the Spp1 locus, which encodes the type 1 cytokine osteoponti”