Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes

By Č. Venclovas, M. Thelen. Nucleic Acids Res., 2000

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Mechanisms of human DNA repair: an update. (2003, background): “Rad17 has been shown to interact directly with the Rad9-1-1 complex in yeast (Venclovas and Thelen, 2000) and in humans (Rauen et al., 2000).”
Surviving the breakup: the DNA damage checkpoint. (2006, background): “This heterotrimeric complex is made up of Rad17, Mec3, and Ddc1, all of which show limited sequence homology to the PCNA clamp (152), and is therefore referred to as a checkpoint clamp.”
The HHpred interactive server for protein homology detection and structure prediction (2005, unknown): “…search methods fail, the recently developed, highly sensitive methods for homology detection or structure prediction (confer, e.g. (4–11) and descriptions and links at http://bioinfo.pl/Meta/servers.html) quite often allow to make inferences from more remotely homologous relationships (12–17).”
Cell cycle checkpoint signaling through the ATM and ATR kinases. (2001, background): “In addition to its predicted role as a checkpoint clamp loader for the Rad1–Rad9–Hus1 complex (Thelen et al. 1999; Venclovas and Thelen 2000), our group has shown that treatment of human cells with genotoxic agents triggers rapid associations of ATM and ATR with hRad17 (Bao et al.”
Toward maintaining the genome: DNA damage and replication checkpoints. (2002, background): “Another complex is a heterotrimeric ring composed of Rad9, Hus1, and Rad1, termed the 9-1-1 complex (23, 28, 84, 179, 198, 201).”