Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).

By C. Thiede, S. Koch, E. Creutzig, Christine Steudel, T. Illmer, M. Schaich, G. Ehninger. Blood, 2006

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DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia (2010, background): “However, when this mutation occurs in the context of an associated FLT3-ITD, then this favorable prognostic impact is lost ( Thiede et al., 2006 ).”
Stem cell gene expression programs influence clinical outcome in human leukemia (2011, background): “Recently, the combined mutational status of FLT3 and NPM1 has been found to designate low molecular risk (NPM1mut FLT3wt; LMR) and high molecular risk (FLT3ITD or NPM1wt FLT3wt; HMR) group”
The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. (2008, neutral): “High-level ITD — — — — — — 52 10 (19) 42 (81) —”
Cancer stem cells: impact, heterogeneity, and uncertainty. (2012, neutral): “…and Look, 2005; Berman et al., 2011; Brown et al., 2007; Downing and Shannon, 2002; Falini et al., 2005; Ho et al., 2011; Kiyoi et al., 1999; Kottaridis et al., 2001; Ley et al., 2010; Meshinchi et al., 2001; Stirewalt et al., 2001; Thiede et al., 2006; Vogelstein et al., 1990; Zwaan et al., 2003).”