Making new contacts: the mTOR network in metabolism and signalling crosstalk

By Mitsugu Shimobayashi, Michael N. Hall. Nature reviews. Molecular cell biology, 2014

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mTOR: a pharmacologic target for autophagy regulation. (2015, neutral): “17, 18).”
Metabolic Control of Longevity. (2016, background): “…and prevents neurodegeneration in various mouse models, ameliorates cardiac function in aging mice, suppresses senescence-associated inflammation, and mediates immunosuppressive effects that are clinically harnessed for the prevention of solid graft rejection (Shimobayashi and Hall, 2014).”
Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “mTORC1 can promote the synthesis of proteins, lipids, and nucleotides by integrating various stimuli and signaling networks and can block catabolic processes such as autophagy.(132,133) Studies”
Nutrient sensing and TOR signaling in yeast and mammals (2017, neutral): “…anabolic processes such as protein, lipid, and nucleotide synthesis, and represses catabolic processes such as autophagy, to ultimately promote cell growth (for review, see Wullschleger et al , 2006; Loewith & Hall, 2011; Howell et al , 2013; Laplante & Sabatini, 2013; Shimobayashi & Hall, 2014).”
Oxidative stress and autophagy: the clash between damage and metabolic needs (2014, background): “of at least two distinct mechanisms, signal amino acid availability to mTORC1 and modulate its activation state.(23) One mechanism suggests that RAGs sense the amino acid”