Comparison of treatment effects between animal experiments and clinical trials: systematic review

By Pablo Perel, I. Roberts, E. Sena, P. Wheble, Catherine Briscoe, P. Sandercock, M. Macleod, L. Mignini, P. Jayaram, Khalid Khan. British medical journal, 2006

762 citations recorded by the source corpus.

Subfields: Hematology, Pediatrics, Perinatology and Child Health, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/646d5daad7626dcec97589a027f5d1f69aeeeec4

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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Xiantao Zeng
2. Yonggang Zhang
3. J. Kwong
4. Chao Zhang
5. Gail A. Van Norman
6. Sheng Li
7. F. Sun
8. Y. Niu

Citations in the corpus

• Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research (2010, neutral): “[22] It is unlikely that this issue is confined to clinical research.[2-14,16-20]”
• Reproducibility in Science: Improving the Standard for Basic and Preclinical Research (2015, neutral): “clinical research is poorly predictive of ultimate success in the clinic.(14,15) And it is observational research that both attracts”
• Lost in translation: animal models and clinical trials in cancer treatment. (2014, background): “Instead, there is a growing awareness of the limitations of animal research and its inability to make reliable predictions for human clinical trials [8].”
• The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta‐analysis, and clinical practice guideline: a systematic review (2015, background): “Before clinical trials are carried out, the safety and effectiveness of new drugs are usually tested in animal models (45), therefore, animal studies are considered as preclinical research and have important significance (46, 47).”
• Biology-inspired Microphysiological System Approaches to Solve the Prediction Dilemma of Substance Testing (2016, neutral): “Leist and Hartung, 2013; Matthews, 2008; Olson et al., 2000; Perel et al., 2007; Hartung and Leist, 2008; Schnerch et al., 2010; Sena et al., 2010; Seok et al., 2013; van der Worp et al., 2010; Hartung, 2013).”
• Can Animal Models of Disease Reliably Inform Human Studies? (2010, background): “Traumatic brain injury [2] 2007 17 2 (12) 3 (18) N/A”
• SYRCLE’s risk of bias tool for animal studies (2014, background): “Nevertheless, many have called for registration of all animal experiments at inception [19,20], so we expect that registration of animal studies will be more common within a few years.”
• The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? (2008, background): “Summary Major discrepancies between drug effects in animal models and in human trials have recently been pointed out, which may be due to design of the models, assessment tools for determination of drug efficacy, and timing of drug application (Perel et al., 2007).”
• The problem of pseudoreplication in neuroscientific studies: is it affecting your analysis? (2010, background): “Registering animal experiments has therefore been suggested as a way to improve the quality of animal studies [41-44] or to have “animal subject committees” to “.”
• Limitations of Animal Studies for Predicting Toxicity in Clinical Trials (2019, background): “A review of 221 animal experiments found agreement in human studies just 50% of the time—essentially randomly (11).”