Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

By B. Varnum‐Finney, Lanwei Xu, C. Brashem-Stein, C. Nourigat, D. Flowers, S. Bakkour, W. Pear, I. Bernstein. Nature Medicine, 2000

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Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size (2005, background): “Stem cell expansion may occur without increased proliferation in the context of Notch1 activation where stem cell self-renewal is favored over differentiation (27, 28).”
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. (2006, background): “Notch influences the self-renewal of hematopoietic stem cells (HSCs) (Varnum-Finney et al. 2000; Calvi et al. 2003; Duncan et al. 2005), T-cell specification from a multipotent precursor (Pui et al.”
Stem cell niche: structure and function. (2005, background): “In this section, we describe and compare the location and physical organization (if known) of adult stem cells in bone marrow, skin/hair follicle, intestine, neuron, and testis.”
Hypoxia requires notch signaling to maintain the undifferentiated cell state. (2005, background): “Notch signaling is an attractive candidate for this process, as it often functions to maintain the stem/progenitor cell state, for example in myogenesis (Nofziger et al., 1999; Dahlqvist et al., 2003) and hematopoiesis (Varnum-Finney et al., 2000).”