Identification of membrane-type receptor for bile acids (M-BAR).

By Takaharu Maruyama, Y. Miyamoto, Takao Nakamura, Y. Tamai, H. Okada, E. Sugiyama, Tatsuji Nakamura, H. Itadani, Ken‐ichi Tanaka. Biochemical and Biophysical Research Communications - BBRC, 2002

949 citations recorded by the source corpus.

Subfields: Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/63528806cea0b44eb307ba92294c6cf168b9eaae

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. J. Y. Chiang
2. Tiangang Li
3. F. Bäckhed
4. Christoph Borner
5. Hanns-Ulrich Marschall
6. S. Ghosh
7. Johan Auwerx
8. A. Wahlström

In Surgery

1. J. Y. Chiang
2. A. Ramachandran
3. Hanns-Ulrich Marschall
4. H. Jaeschke
5. Tiangang Li
6. Johan Auwerx
7. F. Bäckhed
8. A. Wahlström

Citations in the corpus

• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, positive): “79 lM) being the most potent agonists (Kawamata et al. 2003; Maruyama et al. 2002; Sato et al. 2008).”
• Bile acids: regulation of synthesis (2009, background): “adipose tissue, bile acids activate TGR5, a GPCR (35, 36).”
• Bile Acid Signaling in Metabolic Disease and Drug Therapy (2014, background): “Gas protein– coupled receptor TGR5 was recently identified as a bile acid–activated membrane receptor (Maruyama et al., 2002; Kawamata et al., 2003).”
• Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism. (2016, positive): “TGR5 is activated mainly by the secondary bile acids LCA and DCA (Chen et al., 2011; Maruyama et al., 2002) and is therefore an interesting target in the context of microbiota-bile acid interactions (Figure 2).”
• Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “Receptor-specific regulation of ERK1/2 activation by members of the ‘‘free fatty acid receptor’’ family.”
• Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. (2016, background): “Besides the well-established role of BAs in activating the nuclear receptor farnesoid X receptor (FXR) to orchestrate BA, lipid, and glucosemetabolism, BAs also activate the cell membrane receptor TGR5 (transmembrane G proteincoupled receptor-5; also known as GPBAR1 or GPR131) (Kawamata et al., 2003”
• TGR5-mediated bile acid sensing controls glucose homeostasis. (2009, background): “Beyond the orchestration of BA, lipid, and glucose metabolism by the nuclear receptor farnesoid X receptor (FXR), BAs also act as signaling molecules through the BA-dedicated G protein-coupled receptor (GPCR) TGR5 (GPR131) (Kawamata et al., 2003; Maruyama et al., 2002).”