Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

By H. Sies, Dean P. Jones. Nature reviews. Molecular cell biology, 2020

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A guide to cell death pathways (2023, neutral): “Disruption of redox homeostasis leads to the accumulation of ROS, which is common in patients with chronic inflammatory diseases 213 .”
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants (2024, background): “Further addition of an electron to superoxide results in the formation of hydrogen peroxide, an important signaling molecule (Sies et al. 2020; Cadenas et al. 2022; Marinho et al. 2013).”
Role of Glutathione in Cancer: From Mechanisms to Therapies (2020, background): “The itochondrial inner membrane nicotinamide nucleotide transhydrogenase (NNT) also produces NADPH and this serves to couple reductive stress-induced H2O2 production to NT-associated NADPH and glutathione redox mechanisms [17].”