The AMP-activated protein kinase cascade--a unifying system for energy control.

By David Carling. TIBS -Trends in Biochemical Sciences. Regular ed, 2004

1,184 citations recorded by the source corpus.

Subfields: Archeology, Conservation, Earth-Surface Processes

View Paper: https://www.semanticscholar.org/paper/6302a959a81db135a997cd06a621fafe9dd9e739

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Archeology

1. Barry J. Goldstein
2. Rosario Scalia
3. D. Hardie
4. J. Richards
5. J. Suttles
6. Duygu Sag
7. R. Stout
8. J. Testa

In Conservation

1. Barry J. Goldstein
2. Rosario Scalia
3. D. Hardie
4. J. Richards
5. J. Suttles
6. Duygu Sag
7. R. Stout
8. J. Testa

In Earth-Surface Processes

1. Barry J. Goldstein
2. Rosario Scalia
3. D. Hardie
4. J. Richards
5. J. Suttles
6. Duygu Sag
7. R. Stout
8. J. Testa

Citations in the corpus

• Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. (2004, background): “AMP-activated protein kinase (AMPK) is a master regulator of energy metabolism that is activated in response to energy deprivation (Carling 2004).”
• AMP-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype (2008, positive): “Studies demonstrating the role of AMPK in improvement of insulin sensitivity and glucose homeostasis have identified AMPK as target for the treatment of Type 2 diabetes and obesity (11).”
• The Kinome of Pacific Oyster Crassostrea gigas, Its Expression during Development and in Response to Environmental Factors (2016, neutral): “The protein kinase AMPK is a key regulator of cell energy metabolism in eukaryotes [49].”
• Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. (2006, background): “However, subsequent studies reported that energy depletion inhibited mTOR signaling through AMP-activated kinase (AMPK) phosphorylation of TSC2 (Corradetti et al., 2004; Inoki et al., 2003; Shaw et al., 2004 )( Figure 1). This observation would seem to support a pivotal role for AMPK in switching be”
• The AMP-activated protein kinase pathway – new players upstream and downstream (2004, background): “Readers who are particularly interested in aspects related to medicine or physiology should consult other recent reviews (Hardie, 2003; Hardie et al., 2003; Carling, 2004; Hardie, 2004a; Hardie, 2004b).”
• Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. (2007, background): “cellular homeostasis in response to energy stress in all eukaryotic cells (11).”
• Hypoxia-induced energy stress regulates mRNA translation and cell growth. (2006, background): “AMPK is activated through binding of AMP and subsequent phosphorylation by upstream kinases at a threonine residue within the activation loop of the catalytic a subunit (Thr172 in human AMPK) (Carling, 2004).”
• The role of autophagy during the early neonatal starvation period (2004, methodology): “We then assessed the energy status of tissue by measuring the activity of AMP-activated protein kinase (AMPK), which functions as an energy senso”