Human Gut Microbiome: Function Matters.

By A. Heintz‐Buschart, P. Wilmes. Trends in Microbiology, 2017

637 citations recorded by the source corpus.

The human gut microbiome represents a complex ecosystem contributing essential functions to its host. Recent large-scale metagenomic studies have provided insights into its structure and functional potential. However, the functional repertoire which is actually contributed to human physiology remains largely unexplored. Here, by leveraging recent omics datasets, we challenge current assumptions regarding key attributes of the functional gut microbiome, in particular with respect to its variability. We further argue that the closing of existing gaps in functional knowledge should be addressed by a most-wanted gene list, the development and application of molecular and cellular high-throughput measurements, the development and sensible use of experimental models, as well as the direct study of observable molecular effects in the human host.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/62beda6978296994d6e7629b43dbdfb9da19bae4

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In Molecular Biology

Citations in the corpus

Microbiome definition re-visited: old concepts and new challenges (2020, methodology): “method, even in well-studied microbiomes, 40–70% of the annotated genes in fully sequenced microbial genomes have no known or predicted function [114].”
The Human Gut Microbiome: From Association to Modulation. (2018, neutral): “…and need to be interpreted in light of each other, and 708 integrated analysis concepts (Heintz-Buschart et al., 2016; Mallick et al., 2017) start challenging 709 common conceptions on the microbiome, e.g. on the relative importance of functional plasticity 710 (Heintz-Buschart and Wilmes, 2017).”