Epigenetics and aging: the targets and the marks.

By M. Fraga, Manel Esteller. Trends in Genetics, 2007

685 citations recorded by the source corpus.

Subfields: Aging, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/62500ca5a621038347ab3d77ea65467c1e0717fe

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

In Genetics

In Molecular Biology

Citations in the corpus

Aging effects on DNA methylation modules in human brain and blood tissue (2012, background): “Previous studies of aging effects on DNA methylation involved typically adults but recent studies also involved pediatric populations[8] Important insights have been gained regarding what types of genes show promoter hyper- or hypomethylation with age [9-11].”
Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates (2012, positive): “A growing body of research has reported associations between age and the state of the epigenome—the set of modifications to DNA other than changes in the primary nucleotide sequence (Fraga and Esteller, 2007).”
An epigenetic biomarker of aging for lifespan and healthspan (2018, background): “Chronological time has been shown to elicit predictable hypo- and hyper-methylation changes at many regions across the genome [3-7], and as a result, the first generation of DNAm based biomarkers of aging were developed to predict chronological chronological age [8-13].”
DNA methylation age of human tissues and cell types (2013, background): “particular, cancer tissues were excluded from this first large data set since it is well known that cancer has a profound effect on DNA methylation levels [6,7,24-26].”
Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population (2012, background): “On the other hand, environment-dependent changes in DNA methylation in MZ twins have been reported to occur preferentially in gene-poor regions (see [34]).”
DNA methylation age of blood predicts all-cause mortality in later life (2015, neutral): “Unlike genomic variants, such as single nucleotide polymorphisms (SNPs), levels of DNA methylation vary across the life course [2-6].”
DNA methylation and healthy human aging (2015, methodology): “The concept was then used to describe the increase in discordance of DNA methylation between monozygotic twins as they age (Fraga et al., 2005; Fraga & Esteller, 2007; Poulsen et al., 2007).”
Aging of blood can be tracked by DNA methylation changes at just three CpG sites (2014, background): “In particular, DNA methylation (DNAm) is well known to change during aging [10].”
Child health, developmental plasticity, and epigenetic programming. (2011, background): “One of the theories of aging claims that aging is the progressive decay of the potential of adult stem cells to maintain correct tissular homeostasis (331, 332).”
The hallmarks of aging. (2013, background): “Increased histone H4K16 acetylation, H4K20 trimethylation, or H3K4 trimethylation, as well as decreased H3K9 methylation or H3K27 trimethylation, constitute age-associated epigenetic marks (Fraga and Esteller, 2007; Han and Brunet, 2012).”