Junctophilins: a novel family of junctional membrane complex proteins.

By H. Takeshima, S. Komazaki, M. Nishi, M. Iino, K. Kangawa. Molecules and Cells, 2000

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The endoplasmic reticulum: structure, function and response to cellular signaling (2015, background): “Calcium signaling occurs at the contact sites between the plasma membrane and the abutting cortical ER and is necessary for muscle contraction [55, 56].”
Mutation of junctophilin type 2 associated with hypertrophic cardiomyopathy (2007, background): “During the contraction of striated muscle cells, the activation of cell-surface dihydropyridine receptor channels (DHPRs) opens ryanodine receptors Y. Kurihara Department of Pediatrics, St. Marianna University School of Medicine, Kawasaki, Japan N. Kamatani Division of Genomic Medicine, Department o”
Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI (2010, background): “Proteins known to be preferentially localized to ER–plasma membrane contacts, such as junctophilin (117, 118), have thus far not been shown to interact directly with STIM, although such interactions have not been ruled out.”
The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis (2001, background): “MORN repeats are present in phosphatidylinositol signaling protein”