Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms.

By K. Stenmark, K. Fagan, M. Frid. Circulation Research, 2006

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MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2 (2009, neutral): “In particular, this response may be especially important to the pulmonary vascular endothelium, which directly responds to hypoxia by controlling the release of vasoactive effectors, thereby critically influencing normal vascular physiology and the development of pulmonary hypertension (Stenmark et ”
Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure. (2009, background): “Responses are also significantly affected by age, as younger individuals with rapidly maturing lungs are more susceptible to this trigger (154).”
ADAPTIVE AND MALADAPTIVE CARDIORESPIRATORY RESPONSES TO CONTINUOUS AND INTERMITTENT HYPOXIA MEDIATED BY HYPOXIA-INDUCIBLE FACTORS 1 AND 2 (2012, background): “The specific vascular remodeling that is induced by hypoxia is complex and variable, based on species, sex, and age of the host as well as varying among vessels at different sites along the longitudinal axis of the pulmonary vascular tree (319).”
Fibroblasts in fibrosis: novel roles and mediators (2014, background): “Adventitial fibroblasts found in blood vessels can be activated by hypoxia and are implicated as a source of myofibroblasts that promote vascular remodeling and the associated pulmonary hypertension (Stenmark et al., 2006).”