Bacterial insertion sequences: their genomic impact and diversity
By Patricia Siguier, Edith Gourbeyre, Michael Chandler. FEMS Microbiology Reviews, 2014
626 citations recorded by the source corpus.
Abstract Insertion sequences (ISs), arguably the smallest and most numerous autonomous transposable elements (TEs), are important players in shaping their host genomes. This review focuses on prokaryotic ISs. We discuss IS distribution and impact on genome evolution. We also examine their effects on gene expression, especially their role in activating neighbouring genes, a phenomenon of particular importance in the recent upsurge of bacterial antibiotic resistance. We explain how ISs are identified and classified into families by a combination of characteristics including their transposases (Tpases), their overall genetic organisation and the accessory genes which some ISs carry. We then describe the organisation of autonomous and nonautonomous IS‐related elements. This is used to illustrate the growing recognition that the boundaries between different types of mobile element are becoming increasingly difficult to define as more are being identified. We review the known Tpase types, their different catalytic activities used in cleaving and rejoining DNA strands during transposition, their organisation into functional domains and the role of this in regulation. Finally, we consider examples of prokaryotic IS domestication. In a more speculative section, we discuss the necessity of constructing more quantitative dynamic models to fully appreciate the continuing impact of TEs on prokaryotic populations.
Subfields: Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/66ab923d05ab335674e5a325c049fd4c0afe0daf
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Citations in the corpus
- Review of Antimicrobial Resistance in the Environment and Its Relevance to Environmental Regulators (2016, background): “; (b) Are there implications to the environment from chronic exposure to elevated levels of ARGs and the MGEs in which they might be contained?”
- mobileOG-db: a Manually Curated Database of Protein Families Mediating the Life Cycle of Bacterial Mobile Genetic Elements (2021, background): “Current databases of MGEs also contain accessory genes, such as ARGs (5, 25), metal resistance genes (5, 26), or virulence factors (1, 27 – 29), which are irrelevant for element classi fi cation and may themselves be separate targets in genomic analyses (30 – 32) (Fig.”