Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization

By M. Cella, F. Facchetti, A. Lanzavecchia, M. Colonna. Nature Immunology, 2000

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Cd11c+B220+Gr-1+ Cells in Mouse Lymph Nodes and Spleen Display Characteristics of Plasmacytoid Dendritic Cells (2001, methodology): “Stimulation of Th1 polarization by pDCs has also been demonstrated (19), suggesting that pDC T cell polarizing activity is dependent on the methods and stimuli used to activate these cells.”
Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells1 (2004, background): “PDCs have been shown to induce either a Th2 or a Th1 response in naive CD4 T cells depending upon the stimulatory signals (8, 9, 14).”
Blood monocytes: development, heterogeneity, and relationship with dendritic cells. (2009, background): “pDCs are the most potent IFN-α-producing cells in response to viral pathogens (107, 108).”
Plasmacytoid Dendritic Cells: Recent Progress and Open Questions (2011, background): “For instance, pDCs can efficiently prime CD4+ T cell responses in the lymph nodes (100), induce Th1 polarization (101, 102), and prime (103) and cross-prime”