Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo.

By Trista E North, M. D. de Bruijn, T. Stacy, L. Talebian, E. Lind, C. Robin, Michael Binder, E. Dzierzak, N. Speck. Immunity, 2002

628 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/60f218a613233aae1170106f9b865987d20d5b5c

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Citations in the corpus

Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration (2009, neutral): “The Runx1 protein, widely known for its involvement in leukemia, is specifically expressed in the AGM and is required for the formation of functional HSCs (North et al., 2002).”
Fate tracing reveals the endothelial origin of hematopoietic stem cells (2008, background): “At this time, the AGM region (Figures 1B and 1C) reveals preferential labeling of the ventral wall of the dorsal aortic endothelium, an area noted for HSC emergence (de Bruijn et al., 2002; North et al., 2002; Taoudi and Medvinsky, 2007).”
Core-binding factors in haematopoiesis and leukaemia (2002, background): “Fractionation of cells from the AGM region, vitelline and umbilical arteries into those that either express or do not express Runx1 , followed by transplantation into mice, showed that Runx1 expression marks all HSCs in the embry”
Runx1 is required for the endothelial to hematopoietic cell transition but not thereafter (2009, neutral): “As the autonomous production of HSCs occurs first in the major arteries of the conceptus at 10.5 dpc (dorsal aorta, vitelline and umbilical) 19, and HSCs localize to the walls of these arteries 2, 16, we examined intra-arterial cluster formation in Runx1 f/f ;VEC-Cre embryos.”
Hematopoiesis: an evolving paradigm for stem cell biology. (2008, background): “For example, the transcription factor Runx1 is necessary for blood formation from hemogenic endothelium but not from yolk sac hemangioblasts (North et al., 1999, 2002).”