Core-binding factors in haematopoiesis and leukaemia

By N. Speck, D. Gilliland. Nature Reviews. Cancer, 2002

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Origins of chromosome translocations in childhood leukaemia (2003, background): “These same genes are crucial for the normal function of haematopoietic stem cells, as shown by knockout experiments in mic”
Disruption of differentiation in human cancer: AML shows the way (2003, background): “The mechanism of AML1 function and its gene targets are still not well understoo”
Review of (2006, background): “However, they are reported to mediate distinct biological functions in vivo (Okuda et al., 1996; Speck and Gilliland, 2002; Ducy et al., 1997; Levanon et al., 2002; Li et al., 2002).”