COMT val158met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor

By Jon-Kar Zubieta, M. Heitzeg, Y. Smith, Joshua A. Bueller, Ke Xu, Yanjun Xu, Robert A. Koeppe, C. Stohler, David Goldman. Science, 2003

1,167 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/6098bfe07b1f175f8d9e8293d84d41fe581cb138

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

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Citations in the corpus

Human brain mechanisms of pain perception and regulation in health and disease (2005, background): “Reciprocal interactions between catecholaminergic and opioid mechanisms are therefore emerging as important factors in the regulation of responses to pain and their interaction with other environmental and genetic influ- ences (Hagelberg et al., 2002; Zubieta et al., 2003).”
Traditional Chinese Acupuncture and Placebo (Sham) Acupuncture Are Differentiated by Their Effects on μ-Opioid Receptors (MORs) (2009, methodology): “…both short- and long-term effects of TA, areas showing increases in BP included a number of brain regions classically implicated in the regulation of pain and stress in humans (Zubieta et al., 2001, 2003b), such as the amygdala, the dorsal and perigenual anterior cingulate, and the insular cortex.”
Chronic stress, cognitive functioning and mental health. (2011, neutral): “…to Val/Val carriers, healthy adults with the Met/Met genotype report greater sensory and affective ratings of pain following a sustained pain challenge (Zubieta et al., 2003) and increased limbic and prefrontal activation following the presentation of unpleasant stimuli (Smolka et al., 2005).”
A comprehensive review of opioid-induced hyperalgesia. (2011, background): “Further, the reduced capacity to activate the μ-opioid system due to a reduced concentration of endogenous opioids (84) would predict increased pain sensitivity during repeated pain stimulation due to less effective recruitment of endogenous pain inhibition leading to a more pronounced sensitization”
Predictors of Postoperative Pain and Analgesic Consumption: A Qualitative Systematic Review (2009, background): “There has also been suggestion that the catechol-O-methyltransferase (COMT) genotype is associated with pain reports and pain-induced brain opioid receptor binding such that individuals with a particular genotype had a higher sensory and affective pain rating.(95) Another COMT genotype has been repo”
Placebo Effects Mediated by Endogenous Opioid Activity on μ-Opioid Receptors (2005, background): “…has also accumulated as to the involvement of this neurotransmitter system in the adaptation and response to novel and emotionally salient stimuli in both animal models and humans (Kalin et al., 1988; Nelson and Panksepp, 1998; Filliol et al., 2000; Zubieta et al., 2003b; Moles et al., 2004).”
A common neurobiology for pain and pleasure (2008, background): “and concomitantly high endogenous-opioid release during tonic pai”