A Drosophila mechanosensory transduction channel.

By Richard G. Walker, A. Willingham, C. Zuker. Science, 2000

697 citations recorded by the source corpus.

Subfields: Aging, Cellular and Molecular Neuroscience, Ecology

View Paper: https://www.semanticscholar.org/paper/60406037a776d429a175e0ef1549a48b77ce844d

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In Cellular and Molecular Neuroscience

Citations in the corpus

The TRP Superfamily of Cation Channels (2005, background): “elegans TRPN protein appears to be expressed in mechanosensory neurons (15).”
painless, a Drosophila gene essential for nociception. (2003, background): “An antibody to Painless binds to localized ila gene suspected to participate in mechanosensation (Walker et al., 2000).dendritic structures that we hypothesize are involved in nociceptive signaling.”
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. (2006, positive): “TRPN1 (or NOMPC), a proposed mechanosensory transducer in flies ( Walker et al., 2000 ), has 29 ankyrin repeats but is present only in genomes of lower vertebrates and”
Ankyrin repeat: a unique motif mediating protein-protein interactions. (2006, background): “(2) Number of AR Motifs in a Protein . While proteins with up to 29 AR motifs have been identified ( 21 ), the majority of AR proteins contain four to seven AR motifs (22), and no single AR has yet been reported to form a stable folded unit itself (14, 23).”
Molecular basis of mechanosensory transduction (2001, background): “Because the large bristles are hollow and contain a conductive high-K + endolymph (similar to the endolymph of vertebrate hearing and vestibular organs) that also bathes the apical surface of the sensory epithelium, electrical access to the tiny sensory dendrite can be gained by snipping the bristl”
Nociceptor and Hair Cell Transducer Properties of TRPA1, a Channel for Pain and Hearing (2005, background): “…by a large number (17) of ankyrin repeats, a feature in common with another TRP channel , NOMPC (no mechanoreceptor potential C) (TRPN1), that in flies mediates bristle mechanoreception (Walker et al., 2000) and in zebrafish contributes to hair cell mechanoreception (Sidi et al., 2003).”
Ion Channels and Synaptic Viewpoint Organization: Analysis of the Drosophila Genome (2000, background): “Approxi-recently identified Drosophila mechanosensory trans- duction channel mutant nompC (Walker et al., 2000). mately 10% of all synapses in C. elegans are electrical.”