Ion Channels and Synaptic Viewpoint Organization: Analysis of the Drosophila Genome

By J. Littleton, B. Ganetzky. 2000

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Guidelines on nicotine dose selection for in vivo research (2007, background): “Homologybased cloning and genome analysis has identified ten receptors with homology to mammalian nAChRs in Drosophila (Gundelfinger 1992; Littleton and Ganetzky 2000).”
The TRP Superfamily of Cation Channels (2005, background): “Each of the TRPN proteins include 29 ankyrin repeats N-terminal to the six transmembrane segments (15, 16, 189) (Fig.”
A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. (2001, background): “Additionally, more focused studies of Drosophila ion-channel genes (Littleton and Ganetzky 2000) and cancer-gene related sequences (Potter et al. 2000) have been published.”
A Novel Human Nicotinic Receptor Subunit, α10, That Confers Functionality to the α9-Subunit (2002, background): “…the full genome of the nematode Caenorhabditis elegans has revealed the existence of over 40 potential genes encoding nicotinic acetylcholine receptor subunits in this organism (Littleton and Ganetzky, 2000), whereas to date only 16 nAChR subunits have been cloned in vertebrates (Lindstrom, 1997).”
Analysis of functional neuronal connectivity in the Drosophila brain. (2012, methodology): “The Drosophila genome does not encode a P2X2 receptor homolog and previous studies suggest that there are no acute behavioral or physiologic effects of ATP in the absence of transgenic P2X2 (Lima and Miesenböck 2005; Littleton and Ganetzky 2000).”