Regulation of innate immune cell function by mTOR

By T. Weichhart, M. Hengstschläger, Monika Linke. Nature reviews. Immunology, 2015

782 citations recorded by the source corpus.

The innate immune system is central for the maintenance of tissue homeostasis and quickly responds to local or systemic perturbations by pathogenic or sterile insults. This rapid response must be metabolically supported to allow cell migration and proliferation and to enable efficient production of cytokines and lipid mediators. This Review focuses on the role of mammalian target of rapamycin (mTOR) in controlling and shaping the effector responses of innate immune cells. mTOR reconfigures cellular metabolism and regulates translation, cytokine responses, antigen presentation, macrophage polarization and cell migration. The mTOR network emerges as an integrative rheostat that couples cellular activation to the environmental and intracellular nutritional status to dictate and optimize the inflammatory response. A detailed understanding of how mTOR metabolically coordinates effector responses by myeloid cells will provide important insights into immunity in health and disease.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/60274819f18a177b656385d6790f78b77ed5edae

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Lewis C. Cantley
2. S. Pun
3. Heather H Gustafson
4. V. Deretic
5. Chayanon Ngambenjawong

Citations in the corpus

• Progress in tumor-associated macrophage (TAM)-targeted therapeutics (2017, positive): “Mammalian target of rapamycin (mTOR) signaling through mTOR complex 1 (mTORC1) and mTORC2 serves a central role in sensing nutrients, oxygen, and metabolites to direct metabolic programming of these macrophages [127].”
• The PI3K pathway in human disease (2017, positive): “Interestingly, in many contexts, PI3K-mTOR pathway activation by TLRs serves to attenuate the inflammatory response (Weichhart et al., 2015).”
• Autophagy in inflammation, infection, and immunometabolism (2021, background): “AMPK and mTOR work as the yin and the yang of cellular metabolism, and act in opposing ways to control both autophagy (Herzig and Shaw, 2018; Liu and Sabatini, 2020) and immunometabolism, profoundly affecting immune cell function (O’Neill and Hardie, 2013; O’Neill et al., 2016; Weichhart et al., 201”
• Targeting PI3K/Akt signal transduction for cancer therapy (2021, background): “Hence, interventions targeting PI3K signaling may be an effective treatment for some immune and tumor-related diseases.(180) Similarly, the PI3K/Akt pathway affects natural killer (NK) cells.”
• Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization (2017, neutral): “determine macrophage activation phenotype (14, 54).”