Angiopoietin-1 protects the adult vasculature against plasma leakage

By Gavin Thurston, J. Rudge, E. Ioffe, Hao Zhou, Leorah Ross, S. Croll, N. Glazer, J. Holash, D. McDonald, G. Yancopoulos. Nature Medicine, 2000

1,353 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/5ff6753e516b3c780692dde9537fc1bdcde09481

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. Peter Carmeliet
2. Rakesh K. Jain
3. K. Alitalo

In Molecular Biology

1. Rakesh K. Jain
2. J. Joyce
3. Peter Carmeliet
4. Dai Fukumura
5. N. Ferrara
6. K. Alitalo
7. D. Hicklin
8. Lance L. Munn

In Oncology

1. Rakesh K. Jain
2. Dai Fukumura
3. J. Joyce
4. Peter Carmeliet
5. K. Alitalo
6. Lance L. Munn
7. D. Hicklin
8. T. Tammela

Citations in the corpus

• The blood–brain barrier in systemic infection and inflammation (2021, background): “Astrocytes also produce angiopoietin-1, which acts at tie-2 receptors on endothelial cells [70] to promote tyrosine dephosphorylation of occludin, stabilizing tight junctions [71].”
• High interstitial fluid pressure — an obstacle in cancer therapy (2004, background): “fcgi?db=genec ANG1 promotes vessel maturation and has been shown to protect from VEGF-induced vascular leakag”
• Evolving functions of endothelial cells in inflammation (2007, background): “; by contrast, angiopoietin-1, which also signals through TIE2, reduces VEGFA-induced vascular leakag”
• Molecular regulation of vessel maturation (2003, background): “Also, an adenoviral vector engineered to express Ang1 prevents VEGF-induced leakiness of vessel”
• Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells (2001, background): “cotransfected into 293 cells as described previously (18).”
• Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions (2001, methodology): “Mustard oil was painted on the ears of Swiss mice, and extravasation of Evans blue determine”
• Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system (2009, background): “Systemic delivery of ANG1 into adult mice has similar effects that counteract the permeability-inducing effects of VEGF administratio”
• Vascular-specific growth factors and blood vessel formation (2000, background): “, or to whole animals using acute adenoviral deliver”