Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages.

By T. Yokota, K. Oritani, Isao Takahashi, J. Ishikawa, A. Matsuyama, N. Ouchi, S. Kihara, T. Funahashi, A. Tenner, Y. Tomiyama and 1 more. Blood, 2000

1,357 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/5f7a84369ca2ff6e2a42d5a3e8e4b4f5015f6371

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. I. Wood
2. Herbert Tilg
3. P. Trayhurn
4. P. Scherer
5. Jerrold M. Olefsky
6. A. Moschen
7. Sushil Kumar Jain
8. A. Achari

In Epidemiology

1. P. Scherer
2. Herbert Tilg
3. K. Walsh
4. N. Ouchi
5. A. Moschen
6. Jerrold M. Olefsky
7. P. Trayhurn
8. T. Funahashi

Citations in the corpus

• Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. (2001, neutral): “It was also shown to suppress TNF production and phagocytic activity in macrophages (13).”
• The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. (2003, neutral): “Adiponectin also has direct anti-inflammatory effects (24).”
• Endothelial dysfunction in diabetes mellitus (2007, neutral): “Adiponectin attenuates vascular infl ammatory changes, but its effects are reduced by its diminished expression in patients who are obese or have insulin resistance (Ouchi et al 2000, 2001; Yokota et al 2000).”
• Adipokines Mediate Inflammation and Insulin Resistance (2013, background): “Adiponectin inhibits LPS-induced TNF-α production in macrophages through inhibition of NF-κB activation and stimulate the production of anti-inflammatory IL-10 (Yokota et al., 2000; Kumada et al., 2004).”
• Adiponectin: mechanistic insights and clinical implications (2012, background): “In addition, inflammatory functions in macrophages are affected: phagocytic activity is inhibited in human macrophages incubated with adiponectin [61], as is the release of pro-inflammatory cytokines [61, 62].”
• Adipokines in inflammation and metabolic disease (2011, background): “It also abrogates LPS-stimulated TNF production by macrophage”
• Adipokines: inflammation and the pleiotropic role of white adipose tissue (2004, background): “Interestingly, adiponectin (also known as Acrp30, AdipoQ, ApM1 or GBP28), which is synthesised only in adipose tissue, appears to have an anti-inflammatory effect, inhibiting phagocytic activity and TNFa production in macrophages (Ouchi et al. 1999; Yokota et al. 2000).”