De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation.

By Evelien Rysman, K. Brusselmans, Katryn Scheys, L. Timmermans, R. Derua, S. Munck, P. V. Van Veldhoven, D. Waltregny, Veerle W. Daniëls, J. Machiels and 5 more. Cancer Research, 2010

683 citations recorded by the source corpus.

Subfields: Biochemistry, Cancer Research

View Paper: https://www.semanticscholar.org/paper/5f72e7f4249c69ac16ec6707e7b5af638bf3f888

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In Biochemistry

1. A. Schulze

In Cancer Research

1. Eyal Gottlieb
2. Adrian L. Harris
3. A. Schulze
4. G. Semenza

Citations in the corpus

• Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development (2013, background): “It has been reported that the shift from lipid uptake to de novo lipogenesis in cancer cells leads to increased membrane lipid saturation, resulting in higher levels of saturated and monounsaturated phospholipids, potentially protecting cancer cells from oxidative damage by reducing lipid peroxidati”
• Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress (2015, background): “This type of shift is indicative of increased de novo fatty acid synthesis and elongation, which produce mainly saturated fatty acyl-CoA and, to a lesser degree, monounsaturated acyl-CoA (Hilvo et al., 2011; Rysman et al., 2010; Sahar et al., 2014).”
• Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies. (2016, background): “Rysman et al (2014) showed that targeting the de novo lipogenesis in prostate cancer cells by soraphen A (an inhibitor of acetyl Co-carboxylase) can result in an increased level of polyunsaturated fatty acids, strong oxidative stress, and cancer cells could be further sensitized to chemotherapeutic ”
• The interaction between ferroptosis and lipid metabolism in cancer (2020, background): “For example, high saturation levels of membrane lipids protect cancer cells from damage induced by reactive oxygen species (ROS), since saturated membrane lipids are less sensitive to peroxidation.(6,7) More importantly, ferroptosis is driven by lipid peroxidation,(4) and LPO are also involved in ce”
• Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila (2015, neutral): “Whether these fatty acids contribute to the protection of PUFAs in lipid droplets is not yet clear but, in the membranes of cancer cells, they are thought to decrease ROS damage by diluting PUFAs in the phospholipid pool (Rysman et al., 2010).”