Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation.
By V. Rao, S. Misra, Igor V. Boronenkov, R. Anderson, James H. Hurley. 1998
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- S. Sivakumaren
- Diana G. Wang
- Mark Lundquist
- T. Balla
- Mindy I. Davis
- Theresa D. Manz
- M. Paddock
- F. Ferguson
Citations in the corpus
- Targeting the PI5P4K lipid kinase family in cancer using covalent inhibitors (2020, background): “…with SYBR Green Thermo Fisher Scientific Cat# K0251 Deposited Data PI5P4Kα/THZ-P1-2 co-crystal structure This paper PDB: 6OSP PI5P4Kβ crystal structure Rao et al., 1998 PDB: 1BO1 PI5P4Kγ crystal structure Uppenberg et al., 2006 PDB: 2GK9 Experimental Models: Cell Lines HeLa (gender: female)…”
- Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions (2002, background): “Enhanced targeting of the PIPKIα constructs with the C-terminal 26 residues reflects structural or functional features of the phosphatidylinositol phosphate kinases, such as dimer formation, which is required for activity at membrane”
- A Homogeneous, High-Throughput Assay for Phosphatidylinositol 5-Phosphate 4-Kinase with a Novel, Rapid Substrate Preparation (2013, background): “PI5P4Kb has been crystallographically characterized and shows a flattened lysine-containing basic patch that is expected to bind to the phospholipid headgroup on the surface of the lipid membrane [18,19].”
- Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “The X-ray analysis of PIPKII crystals also shows the protein in a dimeric form (1257).”
- Improved prediction of protein-protein binding sites using a support vector machines approach. (2005, background): “…by guest on 25 July 2018 site of the small molecule ATP on phosphatidylinositol phosphate kinase (1bo1; Rao et al., 1998), presumably reflecting some shared properties of small molecule binding sites with protein binding sites.”
- Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development (2013, background): “Inspection of the region corresponding to the “activation loop” (20) whose sequence is reported to correlate with PIP5K versus PIP4K activity (13) suggests that CG17471 encodes a PIP4K activity (Fig.”