Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks.

By Jason A. Burdick, C. Chung, Xinqiao Jia, M. Randolph, Robert Langer. Biomacromolecules, 2005

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Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends (2007, background): “It has been shown to be possible to control the degradation and mechanical behaviour of photopolymerized HA networks (Burdick et al .”
Cell Encapsulation in Biodegradable Hydrogels for Tissue Engineering Applications (2008, neutral): “58 Examples of enzymatically degradable segments used in cell encapsulation strategies include polysaccharide-based gels (e.g., HA 24,57,59,60 and chondroitin sulfate 28,61,62 ) and peptide-based linkages that are susceptible to plasmin 63 or matrix metalloproteinases (MMPs).”
Engineering cartilage tissue. (2008, background): “Increased macromer concentrations significantly increased the network compressive modulus and degradation time while decreasing the swelling ratio and cell viability [124].”