Hedgehog signalling in the mouse requires intraflagellar transport proteins

By Danwei Huangfu, Aimin Liu, A. S. Rakeman, N. Murcia, L. Niswander, K. Anderson. Nature, 2003

1,459 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5ef98d66af2dcb6ae4e513fcbe8c01d27972cfac

How researchers see this paper

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In Genetics

1. C. Hui
2. S. Angers
3. S. Goetz
4. P. Beales
5. N. Katsanis
6. Shinsuke Niwa
7. Yosuke Tanaka
8. Courtney J. Haycraft

In Molecular Biology

1. C. Hui
2. Shinsuke Niwa
3. Yosuke Tanaka
4. S. Angers
5. N. Hirokawa
6. S. Goetz
7. N. Katsanis
8. B. Yoder

Citations in the corpus

• Ciliopathies: an expanding disease spectrum (2011, background): “Genetic studies showed that IFT proteins act at the heart of the Shh pathway, downstream of Ptch1 and Smo and upstream of the Gli transcription factors, where they mediate the production of activated to repressor forms of Gli, thereby regulating Hh pathway activity [16].”
• The Primary Cilium: A Signaling Center During Vertebrate Development (2010, background): “In parallel, genetic studies in mice showed that cilia are essential for signalling through the hedgehog (Hh) pathway, a crucial signalling pathway for organizing the body plan, organogenesis and tumorigenesi”
• Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and Function (2005, background): “[18] proposed two possible models for how IFT may regulate Shh signaling, one suggesting the involvement of a cilia-derived signal that is required for Shh pathway activation and a second model in which IFT has two separate functions, one in ciliogenesis and a second one in intracellular transport.”
• Integrative modeling reveals the molecular architecture of the intraflagellar transport A (IFT-A) complex (2022, background): “For example, IFT is critical for primary cilia assembly in mice, where assembly defects are linked to renal disorders, such as polycystic kidney disease (22), and IFT-dependent defects in Hedgehog signal transduction produce neural tube and skeletal abnormalities (23,24).”
• The Primary Cilium as a Complex Signaling Center (2009, background): “types are lost in the neural tube of most IFT complex B mutants [68].”
• BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “The function of this organelle in NPCs remains unknown, whereas recent works indicate that primary cilia are important sites for signal reception, particularly Sonic hedgehog homolog (Shh) (95, 216).”
• Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis (2005, background): “However, because IFT proteins and cilia have also been implicated in other processes (Huangfu et al., 2003; Tsujikawa and Malicki, 2004), it cannot be formally excluded that the left-right defects are caused by mechanisms unrelated to nodal flow.”