Monocytes: protagonists of infarct inflammation and repair after myocardial infarction.

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Macrophages are required for neonatal heart regeneration. (2014, positive): “Consequently, P1 monocytes/macrophages promote angiogenesis that is essential for cardiac regeneration, while previous studies show that adult-like monocytes/macrophages produce soluble factors that stimulate fibrosis and establish a scar (29).”
Therapeutic siRNA silencing in inflammatory monocytes (2011, background): “The magnitude of inflammation influences infarct size and the degree of post-MI heart failur”
Monocyte recruitment during infection and inflammation (2011, background): “These studies suggest that distinct subsets of monocytes are recruited at different stages of infarction, with the first wave of monocytes facilitating the removal of dead cardiac myocytes and the later phase promoting the resolution of inflammation and tissue repai”
The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis. (2016, background): “of inflammation, (myo)fibroblast proliferation, scar formation, and neovascularization over the next several days (Figure 1).(3,4)”