Stem cell fate dictated solely by altered nanotube dimension

By Seunghan Oh, Karla S. Brammer, Y. J. Li, Dayu Teng, A. Engler, Shu Chien, S. Jin. Proceedings of the National Academy of Sciences of the United States of America, 2009

1,160 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology

View Paper: https://www.semanticscholar.org/paper/5ea66e973b8b0f80799004720941d0c167a73328

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In Biomedical Engineering

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Citations in the corpus

Decellularization Strategies for Regenerative Medicine: From Processing Techniques to Applications (2017, background): “In addition to inducing pronounced changes to cell morphology and gene expression [8–11], nanotopography can regulate the differentiation of stem cells into certain lineages such as neuron [8, 12, 13], muscle [14], and bone [15, 16].”
Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells. (2011, background): “Oh et al.(9) studied hMSCs on various diameters of TiO2 nanotubes and observed a decrease in adhesion but an increase in osteogenic differentiation with increasing nanotube diameter.”
Intrinsic extracellular matrix properties regulate stem cell differentiation. (2010, background): “…shape changes and subsequent differentiation to osteoblast-like cells based on the diameter of the nanotube and not on a specific growth factor cocktail; 100 nm diameter tubes promoted osteocalcin and osteopontin expression versus 30 nm diameter tubes, which induced proliferation (Oh et al., 2009).”
Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs (2009, result): “Analysis on this scale would also be consistent with the increasing evidence of exquisite sensitivity of living cells to size-dependent nanoscale stimulation (8, 32, 33).”
Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate. (2014, methodology): “Other methods include the use of microfabricated cantilevers [35] and”
Geometric cues for directing the differentiation of mesenchymal stem cells (2010, background): “Further, a very recent report by Chien and coworkers studied the differentiation of MSCs on titanium oxide nanotubes and found that larger tubes led to an increased spreading of cells and a corresponding increase in osteogenesis (31).”
The interaction of cells and bacteria with surfaces structured at the nanometre scale. (2010, background): “The mechanisms proposed to explain these results are that in stretched cells on larger nanotubes the cytoskeleton is under tension, which induces differentiation due to concomitant elongation of the nucleus [26,134].”
Recent advance in surface modification for regulating cell adhesion and behaviors (2020, background): “have shown that the adhesion and differentiation characteristics of human bone marrow mesenchymal stem cells can be controlled by growing titanium nanotubes with different diameters [109].”