Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells.

By T. R. Nayak, H. Andersen, Venkata S. Makam, C. Khaw, S. Bae, Xiangfan Xu, P. L. Ee, Jong-Hyun Ahn, B. Hong, G. Pastorin and 1 more. ACS Nano, 2011

875 citations recorded by the source corpus.

Current tissue engineering approaches combine different scaffold materials with living cells to provide biological substitutes that can repair and eventually improve tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their specific differentiation into muscles, bones, and cartilages. One of the key objectives for bone regeneration therapy to be successful is to direct stem cells' proliferation and to accelerate their differentiation in a controlled manner through the use of growth factors and osteogenic inducers. Here we show that graphene provides a promising biocompatible scaffold that does not hamper the proliferation of human mesenchymal stem cells (hMSCs) and accelerates their specific differentiation into bone cells. The differentiation rate is comparable to the one achieved with common growth factors, demonstrating graphene's potential for stem cell research.

Subfields: Biomedical Engineering, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/9fdfd8e91503820cb1fc5e9a503163274b75083c

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In Biomedical Engineering

1. Ali Tamayol
2. Yu Shrike Zhang
3. Mohsen Akbari
4. Ali Khademhosseini
5. Sumit Goenka
6. S. Sant
7. He Shen
8. Zhijun Zhang

In Materials Chemistry

1. Ali Khademhosseini
2. Sumit Goenka
3. S. Sant
4. Yan Cheng
5. He Shen
6. Zhijun Zhang
7. Liming Zhang
8. Yufeng Zheng

Citations in the corpus

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• Graphene oxide/hydroxyapatite composite coatings fabricated by electrophoretic nanotechnology for biological applications (2014, background): “[67] Nayak TR, Andersen H, Makam VS, Khaw C, Bae S, Xu X, et al.”
• Graphene-based nanomaterials for drug delivery and tissue engineering. (2014, background): “G and GO-coated surfaces exhibited accelerated cell adhesion, proliferation and differentiation of hMSCs as compared to those cultured on polydimethylsiloxane (PDMS), polyethylene terephthalate (PET), glass, and Si/SiO2 substrates [149].”
• Graphene-based materials for tissue engineering (2016, background): “Remarkably, graphene can accelerate cellular differentiation without commonly used additional bone growth factors, such as BMP-2, while stem cells did not differentiate in the absence of graphene [144].”