Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

By S. Artandi, Sandy Chang, Shwu-Luan Lee, Scott Alson, G. Gottlieb, L. Chin, R. DePinho. Nature, 2000

1,128 citations recorded by the source corpus.

Subfields: Biotechnology, Genetics, Physiology

View Paper: https://www.semanticscholar.org/paper/5ea5ff3c58fa72077ce84c8ac3bbecb76b2a9ece

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

1. Alec C. Kimmelman
2. M. Blasco
3. J. Campisi
4. Ralph Weissleder
5. D. Eriksson
6. T. Stigbrand
7. M. Pittet

In Genetics

1. M. Blasco
2. Michael R. Stratton
3. Yves Moreau
4. N. Sharpless
5. R. DePinho

In Physiology

1. N. Sharpless
2. Manuel Serrano
3. M. Blasco
4. Alec C. Kimmelman
5. M. Collado
6. N. Bardeesy
7. R. DePinho
8. Peter M. Lansdorp

Citations in the corpus

• Ink4a/Arf expression is a biomarker of aging. (2004, background): “For example, excess activity of p53 has been shown to induce premature aging in mice in multiple tissue types (5, 6).”
• Guidelines for the welfare and use of animals in cancer research (2010, background): “…tumours Breast carcinoma, brain, sarcomas, leukaemia, endocrine Additional loss of Terc Trp53(ER)TAM Breast and other carcinomas, germ-cell tumours (Artandi et al, 2000) (Christophorou et al, 2005) Apc (ApcMIN, ApcD716, ApcD580) Multiple polyps in small intestine Polyps in colon progressing to…”
• Chromothripsis and kataegis induced by telomere crisis (2015, neutral): “Telomere crisis has previously been shown to give rise to aneuploidy, non-reciprocal translocations, and whole-genome reduplication (Artandi et al., 2000; Davoli and de Lange, 2012; Davoli et al., 2010).”
• Chromosome instability is common in human cleavage-stage embryos (2009, background): “However, IVF success rates after FISH-based PGD in our center and b a or or”
• Cellular senescence in cancer and aging. (2007, positive): “Under these conditions, cells proliferate in the presence of rampant chromosomal aberrations, which in turn fuels the development of cancer (Artandi et al., 2000).”
• c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. (2002, background): “Telomeric attri-erating tumor progression via genetic instability. tion can generate complex nonreciprocal chromosomal translocations through fusion-bridge breakage cyclesIntroduction (Artandi et al., 2000).”
• Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development (2011, background): “End-toend chromosome fusions resulting from telomere loss can lead to spiraling cycles of dsDNA breakage, aberrant repair and further chromosomal damage in both daughter cells (Artandi et al., 2000; Gisselsson et al., 2001).”