The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

By Jing Wang, Sarah Hevi, Julia K. Kurash, Hong Lei, F. Gay, J. Bajko, Hui Su, Wei-Sheng Sun, Hua Chang, Guoliang Xu and 3 more. Nature Genetics, 2009

807 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5e8502791975e13dbcdd36240798809806677794

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Citations in the corpus

SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells (2015, background): “It was also reported that LSD1 demethylates lysine residues at non-histone proteins including p53, MYPT1, DNMT1 and E2F1 [7-10].”
Linking DNA methylation and histone modification: patterns and paradigms (2009, background): “In addition, it should be noted that histone and DNA methylation may also be connected by indirect interaction”
DNA methylation: superior or subordinate in the epigenetic hierarchy? (2011, background): “LSD1 also demethylates DNMT1 methylated at K142 to antagonize the effect of SET7.”
Epigenetic modifications and human disease (2010, background): “Several mechanisms have been proposed, mainly suggesting interaction of DNMTs with other epigenetic factor”
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation (2012, background): “The histone H3K4/K9 demethylase LSD1 (also known as KDM1A) is one of the chromatin regulators that have been implicated in the control of early embryogenesi”
Epigenetic Modifications as Therapeutic Targets (2010, background): “Notably, LSD1 can also demethylate DNMT1, resulting in destabilization and loss of global maintenance of DNA methylatio”