Stromal Fibroblasts in Cancer: A Novel Tumor-Promoting Cell Type

By A. Orimo, R. Weinberg. Cell Cycle, 2006

798 citations recorded by the source corpus.

Subfields: Cancer Research, Oncology

View Paper: https://www.semanticscholar.org/paper/5e771e5345daf7ad770a36cb35b01682d71235d0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. R. Weinberg
2. Xiumin Wu
3. Cuiling Zhong
4. A. Richmond
5. A. Richardson
6. Z. Wang
7. N. Ferrara
8. T. Onder

In Oncology

1. R. Weinberg
2. T. Onder
3. C. Scheel
4. A. Richmond
5. A. Richardson
6. Z. Wang
7. D. Raman
8. N. Ferrara

Citations in the corpus

• PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. (2009, background): “The stroma consists of extracellular matrix and mesenchymal cell types, which are fibroblasts and myofibroblasts, various inflammatory cells (Shojaei et al., 2008), endothelial cells, and pericytes (Orimo and Weinberg, 2006).”
• Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts (2010, background): “These cells, passaged for 10 PDs in vitro without ongoing interaction with carcinoma cells, retained their ability to promote tumor growth when coinjected with carcinoma cells into immunodeficient mice (14, 46).”
• Immunity, Inflammation, and Cancer (2010, neutral): “In some cases, the critical chemokines are not produced by cancer cells but are induced in tumor-associated fibroblasts upon interaction with carcinoma cells (Liao et al., 2009;Orimo et al., 2005;Orimo and Weinberg, 2006).”
• Role of chemokines in tumor growth. (2007, background): “The resident fibroblasts undergo changes in the newly modified microenvironment and de-differentiate into myofibroblasts or carcinoma-associated fibroblasts (CAFs) expressing a specific marker, αsmooth muscle actin, that is absent in normal fibroblasts [22-25].”
• CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. (2018, neutral): “Carcinoma-associated fibroblasts (CAFs) are activated fibroblasts (Orimo and Weinberg, 2006) constituting the major stro- mal components in many types of malignancies (Kalluri, 2016).”