AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora
By Yi-hu Dong, Jin‐Ling Xu, Xianzhen Li, Lian-Hui Zhang. 2000
311 citations recorded by the source corpus.
Subfields: Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/5dafe89d59ed76f9ec19a06d253d57be04810713
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In Molecular Biology
In Plant Science
- S. S. Sindhu
- David M. Weller
- Praveen Kumar
- Peter Bossier
- P. Ryan
- Saritha Mohanram
- G. Berg
- T. Paulitz
Citations in the corpus
- Targeting virulence: a new paradigm for antimicrobial therapy (2007, background): “For example, Gram-positive Bacillus species produce acylhomoserine lactonase, an enzyme that hydrolyzes the lactone ring of AHLs, thereby rendering them unable to mediate signalin”
- Biological Control of Soilborne Plant Pathogens with Rhizosphere Bacteria (2009, background): “The engineered leaves and tubers showed little pathogen damage, whereas nontransgenic control plants had severe soft rot symptoms (Dong et al. 2000), demonstrating that engineered plants could degrade AHL signals effectively to block bacterial communication required for pathogenicity.”
- Rhizosphere engineering and management for sustainable agriculture (2009, background): “The aiiA gene from Bacillus sp. ( Dong et al. 2000, 2002 ) was transferred to potato (Solanum tuberosum) to generate transgenic lines that indeed inactivated NAHL (Dong et al. 2001).”
- Rhizosphere microbiome: revisiting the synergy of plant-microbe interactions (2019, background): “Transgenic tobacco and potato plants expressing the aiiA gene responsible for AHL degradation have shown resistance to Erwinia carotovora pv. carotovora infections even at very high bacterial inocula (Dong et al. 2000).”
- Disruption of bacterial quorum sensing: an unexplored strategy to fight infections in aquaculture (2004, background): “Indeed, several in vivo studies showed that the degradation of AHLs might continue until below the level needed for activation of quorum sensing-regulated virulence genes (Dong et al., 2000; Molina et al., 2003; Uroz et al., 2003; Dong et al., 2004).”