Targeting virulence: a new paradigm for antimicrobial therapy

By A. Clatworthy, E. Pierson, D. Hung. Nature Chemical Biology, 2007

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Antimicrobial Resistance and Virulence: a Successful or Deleterious Association in the Bacterial World? (2013, background): “This approach would therefore lead to preservation of susceptible nonpathogenic bacteria, which would act as a barrier for colonization by virulent populations; antibiotic pressure would also be lowered, thus minimizing the risk for horizontal spread of drug resistance genes (430, 431).”
Wall teichoic acids of gram-positive bacteria. (2013, background): “Antivirulence Targets Proponents of virulence factors as antibacterial targets argue that resistance to virulence factor inhibitors is less likely to emerge, because there is no selection pressure for survival (30).”